Quad-Mix is a prescription, compounded injectable medication used to treat erectile dysfunction (ED), particularly in patients who do not achieve adequate results with oral medications or with Trimix. It is formulated by specialized compounding pharmacies and contains four active ingredients: alprostadil, papaverine, phentolamine, and atropine. These medications work synergistically to relax smooth muscle, dilate blood vessels, and significantly increase blood flow to the penis, producing an erection that can begin within 5 minutes of injection and last through climax.

How Does Quad-Mix Work?

Alprostadil: A prostaglandin vasodilator that relaxes smooth muscle and increases arterial blood flow.
Papaverine: A smooth muscle relaxant that enhances penile blood circulation.
Phentolamine: An alpha-blocker that prevents vessel constriction, improving blood inflow.
Atropine: An anticholinergic agent that further relaxes smooth muscle and may enhance the strength and duration of the erection in difficult-to-treat cases.

Because Quad-Mix is custom-compounded, your healthcare provider will prescribe a specific formulation and dosage tailored to your response and medical history.

How to Use Quad-Mix Properly

• Always wash your hands and ensure the penis is clean before injection.
• Gather all necessary supplies: Quad-Mix vial, syringe, alcohol wipes, and a sharps container.
• Store Quad-Mix refrigerated and protected from light when not in use.

• Clean the vial’s rubber stopper with an alcohol pad.
• Draw air into the syringe equal to your prescribed dose, inject this air into the vial, then withdraw the correct amount of medication.
• Remove any air bubbles by gently tapping the syringe before injection.

• Sit or lie in a comfortable position.
• Grasp the head of the penis and gently stretch it outward toward your leg.
• Recommended injection sites are at the 10–2 o’clock or 3–9 o’clock positions along the shaft, avoiding the top (12 o’clock), bottom (6 o’clock), and visible veins.
• Clean the injection site with an alcohol pad.
• Insert the needle at a 90-degree angle into the erectile tissue and inject slowly over about 4 seconds.
• Withdraw the needle and apply firm pressure for 1–3 minutes to reduce bleeding or bruising.

Dosage Guidelines:

• Initial doses are usually very low (often 5–10 units / 0.05–0.1 mL), due to Quad-Mix’s increased potency.
• Increase only as directed by your provider, typically by 1–2 units at a time.
• Never exceed your prescribed maximum dose.
• Do not use Quad-Mix more than three times per week, and always wait at least 24 hours between injections.

Important Safety Tips:

• Never inject into the top, bottom, or visible veins of the penis.
• Alternate injection sides with each use.
• Keep Quad-Mix refrigerated at all times when not in use.
• Dispose of needles in a proper sharps container after each injection.
• Seek immediate medical attention if an erection lasts longer than 4 hours.

Potential Side Effects:

• Injection site pain or burning
• Bleeding or bruising
• Fibrosis or scarring with repeated use
• Priapism (prolonged erection)

Consultation and Training:

Your first Quad-Mix injection should be performed under supervision by a healthcare professional to ensure proper technique and correct dosing. Never self-inject without formal instruction.

Quad-Mix is a powerful and highly effective therapy for severe or treatment-resistant ED when used properly under medical supervision. Always follow your provider’s instructions closely to achieve optimal results while minimizing risks.